Endocrine Abstracts

Introduction: Hypogonadism is a cardinal feature of PWS and was generally attributed to hypothalamic dysfunction. Recently, however, primary gonadal defects were also documented. We characterized the spectrum and causes of hypogonadism in PWS adolescents and adults.Methods: We measured reproductive hormonal profiles of 19 males (m) and 16 females (f) ages 15 to 32 years with genetically confirmed PWS. Puberty was assessed by Tanner staging; blood was sam...